Gene Mutation

CAT 2017 Slot 1 · VARC · Medium · Verbal Ability

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The five sentences (labelled 1,2,3,4, and 5) given in this question, when properly sequenced, form a coherent paragraph. Decide on the proper order for the sentence and key in this sequence of five numbers as your answer.

  1. Scientists have for the first time managed to edit genes in a human embryo to repair a genetic mutation, fuelling hopes that such procedures may one day be available outside laboratory conditions.
  2. The cardiac disease causes sudden death in otherwise healthy young athletes and affects about one in 500 people overall.
  3. Correcting the mutation in the gene would not only ensure that the child is healthy but also prevents transmission of the mutation to future generations.
  4. It is caused by a mutation in a particular gene and a child will suffer from the condition even if it inherits only one copy of the mutated gene.
  5. In results announced in Nature this week, scientists fixed a mutation that thickens the heart muscle, a condition called hypertrophic cardiomyopathy
Answer

15243

Explanation

1 opens the paragraph about gene editing in human embryos. 5 specifies the recent experiment on hypertrophic cardiomyopathy. 2 elaborates on this cardiac disease. 4 explains the cause of the condition. 3 concludes with the impact of correcting the mutation. Thus, 15243 is the logical order.

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